COVID-19 Lifestyle Interventions for Optimal Health

Substantial research indicates that certain dietary and lifestyle patterns offer viable options for improving overall health, especially by reducing inflammation. The anti-inflammatory effects of foods and aspects of how one chooses to live may, in turn, favorably influence and support immune system function as a preventative measure for reducing the risk of illness. Furthermore, in the case of (viral) infection, implementing these changes could significantly offset the severity and sequelae incurred from illness.

While this unprecedented COVID-19 pandemic may be stressful and have mental-emotional ramifications both short- and long-term for individuals, Integrative Nurse Coaches can effectively use this time as an opportunity to redirect patients efforts into an assessment of their current lifestyle and motivate changes that will reduce the immediate risk from acute viral infection, as well as the long term risk of chronic disease. Since lifestyle factors have a large effect on immune function, when working with patients in the era of COVID-19, the modifiable lifestyle factors below are excellent first steps in our coaching relationship with clients and patients.

 

Overall Recommendations: Research indicates that plant-based foods high in phytonutrients, water- and lipid-soluble vitamins, and other antioxidants, as well as dietary fiber, can help downregulate an overactive immune response.

Specific recommendations for patients:

  1. Eat plenty of fruits and vegetables for a wide array of phytonutrients to enhance the gut microbiome.
  2. Consume dietary fiber,  28-35 grams daily, preferably from whole foods.
  3. Reduce or avoid immune offenders such as added sugars and salt, high-glycemic foods (including processed carbohydrates), and excessive saturated fat.

Food and nutrition are major daily input for health and well-being. There are three mechanisms that may be involved in the ability of food-derived compounds to reduce viral infection and severity:

  1. Balancing inflammatory pathways.
  2. Reducing oxidative stress and increasing antioxidant levels.
  3. Harmonizing the gut microbiome.

 

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Overall Recommendations: Both acute and chronic stress can result in dysregulated, suppressed immune function. Under these conditions, susceptibility to illness is more likely. Monitoring stress levels through biofeedback markers such as heart rate variability (HRV) may assist in knowing when to implement stress management strategies and in having a means to assess their efficacy, as well in helping to track resilience-building approaches. Practicing stress-modifying techniques on a regular basis using HRV and other modalities can result in greater resilience when confronted with stressors.

 

 

Overall Recommendations: Due to its restorative and regulatory abilities, sleep has a major influence on immune function and inflammatory signals. Therefore, getting good quality, sufficient quantity (seven to eight hours) and adequate deep phasic bouts of sleep is of utmost importance as part of immune maintenance, as well as during times of recovery from illness. It is advised to have patients practice good sleep hygiene and maintain consistent sleep hours by turning off screens, ensuring the room is cool, quiet, and dark, and setting reminders to go to bed on time.

 

 

Moderate, regular physical activity helps immune system function by raising levels of infection-fighting white blood cells and antibodies, increasing circulation, and decreasing stress hormones. A personalized exercise program can be designed even during homestay by utilizing features in one’s home environment, including apps, the internet, and technology, or by taking the opportunity to experience the calming, immune-supportive effects of being in nature (while, at the same time, social distancing).

Physical activity provides the movement the body needs to oxygenate, circulate blood and nutrients, and eliminate waste from cells, all of which are essential to the function of the immune system. In addition to the blood vessels delivering blood to organ systems, the lymphatic system, present largely in the neck, armpits, and groin, plays a big role in the transport of immune factors. Indeed, the social distancing and homestay that has been recommended by many states and nations may invariably disrupt people’s activity schedules and lead to more sedentary behavior, such as more screen time or sitting, reclining, or being stationary, which could further negatively impact immune activity.[106]

Social relationships and connections are a significant determinant of immune health. The absence of these essential relationships, collectively referred to as social isolation, loneliness, bereavement, and/or conflict, has been implicated in the upregulation of proinflammatory processes and reduced immune functionality (e.g., NK cell activity. Furthermore, those who are socially isolated have heightened response to stressors. Older individuals may be particularly at risk for the effects of loneliness if their immune system is already compromised.[127],[128]

The sum of the research on connection and the immune-inflammatory response is mixed as this connection appears to be influenced by several factors, including the response of the individual and their preferences, personality, and health state, as well as whether or not there is conflict or stress in the interactions. However, if there is a sense of supportive connection through the social network, it appears that immune markers can be favorably influenced.

 

SUMMARY OF CLINICIAN RECOMMENDATIONS FOR OPTIMIZING HEALTH DURING THE COVID-19 PANDEMIC

  • Eat plenty of fruits and vegetables. Aim for 9-13 servings per day of a variety of types for a wide array of phytonutrients to enhance the gut microbiome.
  • Consume dietary fiber, a minimum of 28-35 grams daily, preferably from whole foods.
  • Eat fermented vegetables or other probiotic-containing foods to maintain epithelial health and gut barrier function.
  • Reduce or avoid immune offenders such as added sugars and salt, high-glycemic foods (including processed carbohydrates), and excessive saturated fat.

  • Monitoring stress levels through biofeedback markers such as heart rate variability (HRV) may assist in knowing when to implement stress management strategies and in having a means to assess their efficacy, as well in helping to track resilience-building approaches.
  • Practicing stress-modifying techniques on a regular basis using HRV and other modalities can result in greater resilience when confronted with stressors.

  • Good quality, sufficient quantity (seven to eight hours) and adequate deep phasic bouts of sleep is of utmost importance as part of immune maintenance, as well as during times of recovery from illness.
  • It is advised to have patients practice good sleep hygiene and maintain consistent sleep hours by turning off screens, ensuring the room is cool, quiet, and dark, and setting reminders to go to bed on time.

  • A personalized exercise program can be designed even during homestay by utilizing features in one’s home environment, including apps, the internet, and technology, or by taking the opportunity to experience the calming, immune-supportive effects of being in nature (while, at the same time, social distancing).

  • Encourage reduced exposure to interactions perceived as hostile and non-supportive and, at the same time, emphasize and encourage spending time with people who are positive or affirming.
  • For those people who may be lonely or isolated, as well as those who may be at increased risk of immune compromise, recommend regular social connection as a routine. Ideas might include participating virtually in local community events or in a religious or spiritual group.

  1. Schulze MB, Hoffmann K, Manson JE, et al. Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr. 2005;82(3):675-684. doi:1093/ajcn.82.3.675
  2. Christ A, Lauterbach M, Latz E. Western diet and the immune system: an inflammatory connection. Immunity. 2019;51(5):794-811. doi:1016/j.immuni.2019.09.020
  3. Bonaccio M, Pounis G, Cerletti C, et al. Mediterranean diet, dietary polyphenols and low grade inflammation: results from the MOLI-SANI study. Br J Clin Pharmacol. 2017;83(1):107-113. doi:1111/bcp.12924
  4. Molendijk I, van der Marel S, Maljaars PWJ. Towards a food pharmacy: immunologic modulation through diet. Nutrients. 2019;11(6):E1239. doi:3390/nu11061239
  5. Shapira N. The metabolic concept of meal sequence vs. satiety: glycemic and oxidative responses with reference to inflammation risk, protective principles and Mediterranean diet. Nutrients. 2019;11(10):E2373. doi:3390/nu11102373
  6. Schulze MB, Hoffmann K, Manson JE, et al. Dietary pattern, inflammation, and incidence of type 2 diabetes in women. Am J Clin Nutr. 2005;82(3):675-684. doi:1093/ajcn.82.3.675
  7. Della Corte KW, Perrar I, Penczynski KJ, Schwingshackl L, Herder C, Buyken AE. Effect of dietary sugar intake on biomarkers of subclinical inflammation: a systematic review and meta-analysis of intervention studies. Nutrients. 2018;10(5):E606. doi:3390/nu10050606
  8. Molendijk I, van der Marel S, Maljaars PWJ. Towards a food pharmacy: immunologic modulation through diet. Nutrients. 2019;11(6):E1239. doi:3390/nu11061239
  9. Lopez-Garcia E, Schulze MB, Meigs JB, et al. Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr. 2005;135(3):562-566. doi:1093/jn/135.3.562
  10. Silveira BKS, Oliveira TMS, Andrade PA, Hermsdorff HHM, Rosa COB, Franceschini SDCC. Dietary pattern and macronutrients profile on the variation of inflammatory biomarkers: scientific update [published correction appears in Cardiol Res Pract. 2018;2018:9830287]. Cardiol Res Pract. 2018;2018:4762575. doi:1155/2018/4762575
  11. Silveira BKS, Oliveira TMS, Andrade PA, Hermsdorff HHM, Rosa COB, Franceschini SDCC. Dietary pattern and macronutrients profile on the variation of inflammatory biomarkers: scientific update [published correction appears in Cardiol Res Pract. 2018;2018:9830287]. Cardiol Res Pract. 2018;2018:4762575. doi:1155/2018/4762575
  12. Emerson SR, Kurti SP, Harms CA, et al. Magnitude and timing of the postprandial inflammatory response to a high-fat meal in healthy adults: a systematic review. Adv Nutr. 2017;8(2):213-225. doi:3945/an.116.014431
  13. Gore AC, Chappell VA, Fenton SE, et al. EDC-2: the Endocrine Society’s second scientific statement on endocrine-disrupting chemicals. Endocr Rev. 2015;36(6):E1-E150. doi:1210/er.2015-1010
  14. Simopoulos AP. Omega-3 fatty acids and athletics. Curr Sports Med Rep. 2007;6(4):230-236.
  15. Simopoulos AP. Omega-3 fatty acids and athletics. Curr Sports Med Rep. 2007;6(4):230-236.
  16. Molendijk I, van der Marel S, Maljaars PWJ. Towards a food pharmacy: immunologic modulation through diet. Nutrients. 2019;11(6):E1239. doi:3390/nu11061239
  17. Kleinewietfeld M, Manzel A, Titze J, et al. Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature. 2013;496(7446):518-522. doi:1038/nature11868
  18. Zhu F, Du B, Xu B. Anti-inflammatory effects of phytochemicals from fruits, vegetables, and food legumes: a review. Crit Rev Food Sci Nutr. 2018;58(8):1260-1270. doi:1080/10408398.2016.1251390
  19. Medina-Remón A, Casas R, Tressserra-Rimbau A, et al. Polyphenol intake from a Mediterranean diet decreases inflammatory biomarkers related to atherosclerosis: a substudy of the PREDIMED trial. Br J Clin Pharmacol. 2017;83(1):114-128. doi:1111/bcp.12986
  20. Chen L, Teng H, Jia Z, et al. Intracellular signaling pathways of inflammation modulated by dietary flavonoids: the most recent evidence. Crit Rev Food Sci Nutr. 2018;58(17):2908-2924. doi:1080/10408398.2017.1345853
  21. Wisnuwardani RW, De Henauw S, Ferrari M, et al. Total polyphenol intake is inversely associated with a pro/anti-inflammatory biomarker ratio in European adolescents of the HELENA study. J Nutr. Published online March 28, 2020. doi:1093/jn/nxaa064
  22. Molendijk I, van der Marel S, Maljaars PWJ. Towards a food pharmacy: immunologic modulation through diet. Nutrients. 2019;11(6):E1239. doi:3390/nu11061239
  23. Ghanim H, Sia CL, Upadhyay M, et al. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and toll-like receptor expression [published correction appears in Am J Clin Nutr. 2011;93(3):674. Upadhyay, Mannish [corrected to Upadhyay, Manish]]. Am J Clin Nutr. 2010;91(4):940-949. doi:3945/ajcn.2009.28584
  24. Van der Lugt T, Weseler AR, Gebbink WA, Vrolijk MF, Opperhuizen A, Bast A. Dietary advanced glycation endproducts induce an inflammatory response in human macrophages in vitro. Nutrients. 2018;10(12):E1868. doi:3390/nu10121868
  25. Birlouez-Aragon I, Saavedra G, Tessier FJ, et al. A diet based on high-heat-treated foods promotes risk factors for diabetes mellitus and cardiovascular diseases. Am J Clin Nutr. 2010;91(5):1220-1226. doi:3945/ajcn.2009.28737
  26. Report of the joint WHO/FAO Expert Consultation. Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser. 2003;916:i-viii, 1-149. [link]
  27. Halvorsen BL, Carlsen MH, Phillips KM, et al. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr. 2006;84(1):95-135. doi:1093/ajcn/84.1.95
  28. Halvorsen BL, Carlsen MH, Phillips KM, et al. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr. 2006;84(1):95-135. doi:1093/ajcn/84.1.95
  29. Halvorsen BL, Carlsen MH, Phillips KM, et al. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr. 2006;84(1):95-135. doi:1093/ajcn/84.1.95
  30. Halvorsen BL, Carlsen MH, Phillips KM, et al. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr. 2006;84(1):95-135. doi:1093/ajcn/84.1.95
  31. Halvorsen BL, Carlsen MH, Phillips KM, et al. Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr. 2006;84(1):95-135. doi:1093/ajcn/84.1.95
  32. Molendijk I, van der Marel S, Maljaars PWJ. Towards a food pharmacy: immunologic modulation through diet. Nutrients. 2019;11(6):E1239. doi:3390/nu11061239
  33. Venter C, Eyerich S, Sarin T, Klatt KC. Nutrition and the immune system: a complicated tango. Nutrients. 2020;12(3):E818. doi:3390/nu12030818
  34. Fu X, Liu Z, Zhu C, Mou H, Kong Q. Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria. Crit Rev Food Sci Nutr. 2019;59(Suppl 1):S130-S152. doi:1080/10408398.2018.1542587
  35. Venter C, Eyerich S, Sarin T, Klatt KC. Nutrition and the immune system: a complicated tango. Nutrients. 2020;12(3):E818. doi:3390/nu12030818
  36. Venter C, Eyerich S, Sarin T, Klatt KC. Nutrition and the immune system: a complicated tango. Nutrients. 2020;12(3):E818. doi:3390/nu12030818
  37. Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. National Academies Press; 2005:589-768. doi:17226/10490
  38. Senger DR, Li D, Jaminet SC, Cao S. Activation of the Nrf2 cell defense pathway by ancient foods: disease prevention by important molecules and microbes lost from the modern Western diet. PLoS One. 2016;11(2):e0148042. doi:1371/journal.pone.0148042
  39. Kok CR, Hutkins R. Yogurt and other fermented foods as sources of health-promoting bacteria. Nutr Rev. 2018;76(Suppl 1):4-15. doi:1093/nutrit/nuy056
  40. Morris JA. Optimise the microbial flora with milk and yoghurt to prevent disease. Med Hypotheses. 2018;114:13-17. doi:1016/j.mehy.2018.02.031
  41. Yamamoto Y, Saruta J, Takahashi T, et al. Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: a randomized controlled trial. Acta Odontol Scand. 2019;77(7):517-524. doi:1080/00016357.2019.1609697
  42. Yamane T, Sakamoto T, Nakagaki T, Nakano Y. Lactic acid bacteria from kefir increase cytotoxicity of natural killer cells to tumor cells. Foods. 2018;7(4):E48. doi:3390/foods7040048
  43. Azad MAK, Sarker M, Wan D. Immunomodulatory effects of probiotics on cytokine profiles. Biomed Res Int. 2018;2018:8063647. doi:1155/2018/8063647
  44. Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10(11):E1618. doi:3390/nu10111618
  45. Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10(11):E1618. doi:3390/nu10111618
  46. Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10(11):E1618. doi:3390/nu10111618
  47. Yahfoufi N, Alsadi N, Jambi M, Matar C. The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients. 2018;10(11):E1618. doi:3390/nu10111618
  48. Heiman ML, Greenway FL. A healthy gastrointestinal microbiome is dependent on dietary diversity. Mol Metab. 2016;5(5):317-320. doi:1016/j.molmet.2016.02.005
  49. Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500(7464):541-546. doi:1038/nature12506
  50. Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500(7464):541-546. doi:1038/nature12506
  51. Cotillard A, Kennedy SP, Kong LC, et al. Dietary intervention impact on gut microbial gene richness. Nature. 2013;500(7464):585-588. doi:1038/nature12480
  52. Cotillard A, Kennedy SP, Kong LC, et al. Dietary intervention impact on gut microbial gene richness. Nature. 2013;500(7464):585-588. doi:1038/nature12480
  53. Heiman ML, Greenway FL. A healthy gastrointestinal microbiome is dependent on dietary diversity. Mol Metab. 2016;5(5):317-320. doi:1016/j.molmet.2016.02.005
  54. Royo-Bordonada MA, Gorgojo L, Ortega H, et al. Greater dietary variety is associated with better biochemical nutritional status in Spanish children: the Four Provinces Study. Nutr Metab Cardiovasc Dis. 2003;13(6):357-364. doi:1016/s0939-4753(03)80004-2
  55. Foote JA, Murphy SP, Wilkens LR, Basiotis PP, Carlson A. Dietary variety increases the probability of nutrient adequacy among adults. J Nutr. 2004;134(7):1779-1785. doi:1093/jn/134.7.1779
  56. Roduit C, Frei R, Depner M, et al. Increased food diversity in the first year of life is inversely associated with allergic diseases. J Allergy Clin Immunol. 2014;133(4):1056-1064. doi:1016/j.jaci.2013.12.1044
  57. Nwaru BI, Takkinen HM, Kaila M, et al. Food diversity in infancy and the risk of childhood asthma and allergies. J Allergy Clin Immunol. 2014;133(4):1084-1091. doi:1016/j.jaci.2013.12.1069
  58. Thompson HJ, Heimendinger J, Diker A, et al. Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake. J Nutr. 2006;136(8):2207-2212. doi:1093/jn/136.8.2207
  59. Thompson HJ, Heimendinger J, Diker A, et al. Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake. J Nutr. 2006;136(8):2207-2212. doi:1093/jn/136.8.2207
  60. Toribio-Mateas M. Harnessing the power of microbiome assessment tools as part of neuroprotective nutrition and lifestyle medicine interventions. Microorganisms. 2018;6(2):E35. doi:3390/microorganisms6020035
  61. Csaba G. Hormesis and immunity: a review. Acta Microbiol Immunol Hung. 2019;66(2):155-168. doi:1556/030.65.2018.036
  62. Segerstrom SC, Miller GE. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull. 2004;130(4):601-630. doi:1037/0033-2909.130.4.601
  63. Ader R. Psychoneuroimmunology. ILAR J. 1998;39(1):27-29. doi:1093/ilar.39.1.27
  64. Agarwal SK, Marshall GD Jr. Stress effects on immunity and its application to clinical immunology. Clin Exp Allergy. 2001;31(1):25-31.
  65. Marshall GD Jr. The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases. Immunol Allergy Clin North Am. 2011;31(1):133-140. doi:1016/j.iac.2010.09.013
  66. Klein TW. Stress and infections. J Fla Med Assoc. 1993;80(6):409-411.
  67. Aich P, Potter AA, Griebel PJ. Modern approaches to understanding stress and disease susceptibility: a review with special emphasis on respiratory disease. Int J Gen Med. 2009;2:19-32. doi:2147/ijgm.s4843
  68. Marshall GD Jr. The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases. Immunol Allergy Clin North Am. 2011;31(1):133-140. doi:1016/j.iac.2010.09.013
  69. Marshall GD Jr. The adverse effects of psychological stress on immunoregulatory balance: applications to human inflammatory diseases. Immunol Allergy Clin North Am. 2011;31(1):133-140. doi:1016/j.iac.2010.09.013
  70. Freier E, Weber CS, Nowottne U, et al. Decrease of CD4(+)FOXP3(+) T regulatory cells in the peripheral blood of human subjects undergoing a mental stressor. Psychoneuroendocrinology. 2010;35(5):663-673. doi:1016/j.psyneuen.2009.10.005
  71. Gouin JP, Kiecolt-Glaser JK. The impact of psychological stress on wound healing: methods and mechanisms. Immunol Allergy Clin North Am. 2011;31(1):81-93. doi:1016/j.iac.2010.09.010
  72. Buric I, Farias M, Jong J, Mee C, Brazil IA. What is the molecular signature of mind-body interventions? A systematic review of gene expression changes induced by meditation and related practices. Front Immunol. 2017;8:670. doi:3389/fimmu.2017.00670
  73. The American Institute of Stress. Stress mastery questionnaire (SMQ). Accessed April 4, 2020. https://www.stress.org/self-assessment
  74. Williams DP, Koenig J, Carnevali L, et al. Heart rate variability and inflammation: a meta-analysis of human studies. Brain Behav Immun. 2019;80:219-226. doi:1016/j.bbi.2019.03.009
  75. Woody A, Figueroa WS, Benencia F, Zoccola PM. Stress-induced parasympathetic control and its association with inflammatory reactivity. Psychosom Med. 2017;79(3):306-310. doi:1097/PSY.0000000000000426
  76. Horn EE, Turkheimer E, Strachan E. Psychological distress, emotional stability, and emotion regulation moderate dynamics of herpes simplex virus type 2 recurrence. Ann Behav Med. 2015;49(2):187-198. doi:1007/s12160-014-9640-9
  77. Strachan E, Saracino M, Selke S, Magaret A, Buchwald D, Wald A. The effects of daily distress and personality on genital HSV shedding and lesions in a randomized, double-blind, placebo-controlled, crossover trial of acyclovir in HSV-2 seropositive women. Brain Behav Immun. 2011;25(7):1475-1481. doi:1016/j.bbi.2011.06.003
  78. Buric I, Farias M, Jong J, Mee C, Brazil IA. What is the molecular signature of mind-body interventions? A systematic review of gene expression changes induced by meditation and related practices. Front Immunol. 2017;8:670. doi:3389/fimmu.2017.00670
  79. Buric I, Farias M, Jong J, Mee C, Brazil IA. What is the molecular signature of mind-body interventions? A systematic review of gene expression changes induced by meditation and related practices. Front Immunol. 2017;8:670. doi:3389/fimmu.2017.00670
  80. Li QZ, Li P, Garcia GE, Johnson RJ, Feng L. Genomic profiling of neutrophil transcripts in Asian qigong practitioners: a pilot study in gene regulation by mind-body interaction. J Altern Complement Med. 2005;11(1):29-39. doi:1089/acm.2005.11.29
  81. Scott TL, Masser BM, Pachana NA. Exploring the health and wellbeing benefits of gardening for older adults. Ageing Soc. 2015;35(10):2176-2200. doi:1017/S0144686X14000865
  82. Detweiler MB, Self JA, Lane S, et al. Horticultural therapy: a pilot study on modulating cortisol levels and indices of substance craving, posttraumatic stress disorder, depression, and quality of life in veterans. Altern Ther Health Med. 2015;21(4):36-41.
  83. Ng KST, Sia A, Ng MKW, et al. Effects of horticultural therapy on Asian older adults: a randomized controlled trial. Int J Environ Res Public Health. 2018;15(8):E1705. doi:3390/ijerph15081705
  84. Nicholas SO, Giang AT, Yap PLK. The effectiveness of horticultural therapy on older adults: a systematic review. J Am Med Dir Assoc. 2019;20(10):1351.e1-1351.e11. doi:1016/j.jamda.2019.06.021
  85. Lehmann LP, Detweiler JG, Detweiler MB. Veterans in substance abuse treatment program self-initiate box gardening as a stress reducing therapeutic modality. Complement Ther Med. 2018;36:50-53. doi:1016/j.ctim.2017.10.013
  86. Buric I, Farias M, Jong J, Mee C, Brazil IA. What is the molecular signature of mind-body interventions? A systematic review of gene expression changes induced by meditation and related practices. Front Immunol. 2017;8:670. doi:3389/fimmu.2017.00670
  87. Ibarra-Coronado EG, Pantaleón-Martínez AM, Velazquéz-Moctezuma J, et al. The bidirectional relationship between sleep and immunity against infections. J Immunol Res. 2015;2015:678164. doi:1155/2015/678164
  88. Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease. Physiol Rev. 2019;99(3):1325-1380. doi:1152/physrev.00010.2018
  89. Irwin MR, Opp MR. Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology. 2017;42(1):129-155. doi:1038/npp.2016.148
  90. Ibarra-Coronado EG, Pantaleón-Martínez AM, Velazquéz-Moctezuma J, et al. The bidirectional relationship between sleep and immunity against infections. J Immunol Res. 2015;2015:678164. doi:1155/2015/678164
  91. Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease. Physiol Rev. 2019;99(3):1325-1380. doi:1152/physrev.00010.2018
  92. Monaco S, Mariotto S, Ferrari S, et al. Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders: advances in 2015. World J Gastroenterol. 2015;21(42):11974-11983. doi:3748/wjg.v21.i42.11974
  93. Fang I, Tooley D, Gatewood C, Renegar KB, Majde JA, Krueger JM. Differential effects of total and upper airway influenza viral infection on sleep in mice. Sleep. 1996;19(4):337-342.
  94. Drake CL, Roehrs TA, Royer H, Koshorek G, Turner RB, Roth T. Effects of an experimentally induced rhinovirus cold on sleep, performance, and daytime alertness. Physiol Behav. 2000;71(1-2):75-81. doi:1016/s0031-9384(00)00322-x
  95. Irwin MR, Opp MR. Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology. 2017;42(1):129-155. doi:1038/npp.2016.148
  96. Irwin MR, Opp MR. Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology. 2017;42(1):129-155. doi:1038/npp.2016.148
  97. Irwin MR, Olmstead R, Carroll JE. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry. 2016;80(1):40-52. doi:1016/j.biopsych.2015.05.014
  98. Carroll JE, Irwin MR, Stein Merkin S, Seeman TE. Sleep and multisystem biological risk: a population-based study. PLoS One. 2015;10(2):e0118467. doi:1371/journal.pone.0118467
  99. Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease. Physiol Rev. 2019;99(3):1325-1380. doi:1152/physrev.00010.2018
  100. Nishitani N, Sakakibara H. Subjective poor sleep and white blood cell count in male Japanese workers. Ind Health. 2007;45(2):296-300. doi:2486/indhealth.45.296
  101. Basner M, Rao H, Goel N, Dinges DF. Sleep deprivation and neurobehavioral dynamics. Curr Opin Neurobiol. 2013;23(5):854-863. doi:1016/j.conb.2013.02.008
  102. Banks S, Van Dongen HP, Maislin G, Dinges DF. Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery. Sleep. 2010;33(8):1013-1026. doi:1093/sleep/33.8.1013
  103. Belenky G, Wesensten NJ, Thorne DR, et al. Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study. J Sleep Res. 2003;12(1):1-12. doi:1046/j.1365-2869.2003.00337.x
  104. Dinges DF, Douglas SD, Zaugg L, et al. Leukocytosis and natural killer cell function parallel neurobehavioral fatigue induced by 64 hours of sleep deprivation. J Clin Invest. 1994;93(5):1930-1939. doi:1172/JCI117184
  105. Ruiz FS, Andersen ML, Martins RC, Zager A, Lopes JD, Tufik S. Immune alterations after selective rapid eye movement or total sleep deprivation in healthy male volunteers. Innate Immun. 2012;18(1):44-54. doi:1177/1753425910385962
  106. Weyh C, Krüger K, Strasser B. Physical activity and diet shape the immune system during aging. Nutrients. 2020;12(3):E622. doi:3390/nu12030622
  107. Zhu W. Should, and how can, exercise be done during a coronavirus outbreak? An interview with Dr. Jeffrey A. Woods. J Sport Health Sci. 2020;9(2):105-107. doi:1016/j.jshs.2020.01.005
  108. Dimitrov S, Hulteng E, Hong S. Inflammation and exercise: inhibition of monocytic intracellular TNF production by acute exercise via ?2-adrenergic activation. Brain Behav Immun. 2017;61:60-68. doi:1016/j.bbi.2016.12.017
  109. Barrett B, Hayney MS, Muller D, et al. Meditation or exercise for preventing acute respiratory infection: a randomized controlled trial. Ann Fam Med. 2012;10(4):337-346. doi:1370/afm.1376
  110. Nieman DC, Wentz LM. The compelling link between physical activity and the body’s defense system. J Sport Health Sci. 2019;8(3):201-217. doi:1016/j.jshs.2018.09.009
  111. Zhu W. Should, and how can, exercise be done during a coronavirus outbreak? An interview with Dr. Jeffrey A. Woods. J Sport Health Sci. 2020;9(2):105-107. doi:1016/j.jshs.2020.01.005
  112. Campbell JP, Turner JE. Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan. Front Immunol. 2018;9:648. doi:3389/fimmu.2018.00648
  113. Sarin HV, Gudelj I, Honkanen J, et al. Molecular pathways mediating immunosuppression in response to prolonged intensive physical training, low-energy availability, and intensive weight loss. Front Immunol. 2019;10:907. doi:3389/fimmu.2019.00907
  114. Zhu W. Should, and how can, exercise be done during a coronavirus outbreak? An interview with Dr. Jeffrey A. Woods. J Sport Health Sci. 2020;9(2):105-107. doi:1016/j.jshs.2020.01.005
  115. Simpson RJ, Campbell JP, Gleeson M, et al. Can exercise affect immune function to increase susceptibility to infection? Exerc Immunol Rev. 2020;26:8-22.
  116. Yang Y, Verkuilen J, Rosengren KS, et al. Effects of a taiji and qigong intervention on the antibody response to influenza vaccine in older adults. Am J Chin Med. 2007;35(4):597-607. doi:1142/S0192415X07005090
  117. Falkenberg RI, Eising C, Peters ML. Yoga and immune system functioning: a systematic review of randomized controlled clinical trials. J Behav Med. 2018;41(4):467-482. doi:1007/s10865-018-9914-y
  118. Chen P, Mao L, Nassis GP, Harmer P, Ainsworth BE, Li F. Coronavirus disease (COVID-19): the need to maintain regular physical activity while taking precautions. J Sport Health Sci. 2020;9(2):103-104. doi:1016/j.jshs.2020.02.001
  119. Tate DF, Lyons EJ, Valle CG. High-tech tools for exercise motivation: use and role of technologies such as the internet, mobile applications, social media, and video games. Diabetes Spectr. 2015;28(1):45-54. doi:2337/diaspect.28.1.45
  120. Hansen MM, Jones R, Tocchini K. Shinrin-yoku (forest bathing) and nature therapy: a state-of-the-art review. Int J Environ Res Public Health. 2017;14(8):E851. doi:3390/ijerph14080851
  121. Zhu W. If you are physically fit, you will live a longer and healthier life: an interview with Dr. Steven N. Blair. J Sport Health Sci. 2019;8(6):524-526. doi:1016/j.jshs.2019.09.006
  122. US Department of Health and Human Services. Physical Activity Guidelines for Americans. 2nd ed. US Department of Health and Human Services; 2018. Accessed April 4, 2020. https://health.gov/sites/default/files/2019-09/Physical_Activity_Guidelines_2nd_edition.pdf
  123. Leschak CJ, Eisenberger NI. Two distinct immune pathways linking social relationships with health: inflammatory and antiviral processes. Psychosom Med. 2019;81(8):711-719. doi:1097/PSY.0000000000000685
  124. Eisenberger NI, Moieni M, Inagaki TK, Muscatell KA, Irwin MR. In sickness and in health: the co-regulation of inflammation and social behavior. Neuropsychopharmacology. 2017;42(1):242-253. doi:1038/npp.2016.141
  125. Segerstrom SC. Social networks and immunosuppression during stress: relationship conflict or energy conservation? Brain Behav Immun. 2008;22(3):279-284. doi:1016/j.bbi.2007.10.011
  126. Eisenberger NI, Moieni M, Inagaki TK, Muscatell KA, Irwin MR. In sickness and in health: the co-regulation of inflammation and social behavior. Neuropsychopharmacology. 2017;42(1):242-253. doi:1038/npp.2016.141
  127. Luanaigh CO, Lawlor BA. Loneliness and the health of older people. Int J Geriatr Psychiatry. 2008;23(12):1213-1221. doi:1002/gps.2054
  128. Cruces J, Venero C, Pereda-Pérez I, De la Fuente M. A higher anxiety state in old rats after social isolation is associated to an impairment of the immune response. J Neuroimmunol. 2014;277(1-2):18-25. doi:1016/j.jneuroim.2014.09.011
  129. Leschak CJ, Eisenberger NI. Two distinct immune pathways linking social relationships with health: inflammatory and antiviral processes. Psychosom Med. 2019;81(8):711-719. doi:1097/PSY.0000000000000685
  130. Segerstrom SC. Social networks and immunosuppression during stress: relationship conflict or energy conservation? Brain Behav Immun. 2008;22(3):279-284. doi:1016/j.bbi.2007.10.011
  131. Inagaki TK, Muscatell KA, Irwin MR, Cole SW, Eisenberger NI. Inflammation selectively enhances amygdala activity to socially threatening images. Neuroimage. 2012;59(4):3222-3226. doi:1016/j.neuroimage.2011.10.090
  132. Holmes L, Chinaka C, Elmi H, et al. Implication of spiritual network support system in epigenomic modulation and health trajectory. Int J Environ Res Public Health. 2019;16(21):E4123. doi:3390/ijerph16214123
  133. Walker E, Ploubidis G, Fancourt D. Social engagement and loneliness are differentially associated with neuro-immune markers in older age: time-varying associations from the English Longitudinal Study of Ageing. Brain Behav Immun. 2019;82:224-229. doi:1016/j.bbi.2019.08.189
  134. Kornienko O, Schaefer DR, Pressman SD, Granger DA. Associations between secretory immunoglobulin A and social network structure. Int J Behav Med. 2018;25(6):669-681. doi:1007/s12529-018-9742-z

 

As Co-Founder of the International Nurse Coach Association for over a decade, Susan has been teaching and developing coaching program and currently through the Integrative Nurse Coach® Academy. She is Board Certified in Health and Wellness Coaching, Holistic Nursing, and Clinical Nutrition. Susan has authored several chapters on Nutrition and Environmental Health for Holistic Nursing, Integrative Nursing, and Nurse Leadership textbooks. She has co-authored Nurse Coaching and Self-Assessment chapters in; Holistic Nursing: A Handbook for Practice, 7th edition (2015-2020) and is co-author of the award winning book (ANA Gold Seal, 2015) Nurse Coaching: Integrative Approaches for Health and Wellbeing (2015) and The Art and Science of Nurse Coaching, an ANA Publication (2013), that led the way to establishing the standards for practice in the emerging Nurse Coach role. For the past 20 years, she has been the Nurse Coach and Nutrition consultant for Special Immunology Services at Mercy Hospital in Miami and is currently the Director of Nurse Coaching at Rezilir Health in Hollywood, Florida. Susan continues to integrate lifestyle health and wellness education into diverse communities, bringing her expertise and passion as a nurse, clinical nutritionist, and medical anthropologist. She has developed and implemented integrative health initiatives for diverse community organizations including the Yellow Courtyard, Integrative Health Symposium, Urban Zen, New York Open Center, The Lower East Side Girls Club, Kripalu, Omega Institute, and the University of Miami and Florida Atlantic University. As a concerned global citizen, Susan is the founder and education director of the Earthrose Institute, a not-for-profit organization dedicated to environmental health education and advocacy. She maintains a private practice as an Integrative Nurse Coach® with a focus on nutrition and the environment.

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